Tissue resident memory B cells mediate local anti-cancer immunity

Tissue resident memory B cells mediate local anti-cancer immunity
Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions

Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions
ATP citrate lyase regulates fatty acid synthesis and chemosensitivity in triple negative breast cancer

ATP citrate lyase regulates fatty acid synthesis and chemosensitivity in triple negative breast cancer
Remodeling of the tumor immune microenvironment by efineptakin alfa (NT-I7)

Remodeling of the tumor immune microenvironment by efineptakin alfa (NT-I7)
Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma

Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma
HP-MRI as a minimally invasive modality for the early detection and monitoring the progression of pre-malignant lesions with the pancreas from mouse to human

HP-MRI as a minimally invasive modality for the early detection and monitoring the progression of pre-malignant lesions with the pancreas from mouse to human
Characterization of perivascular macrophages and their role in the glioma microenvironment

Characterization of perivascular macrophages and their role in the glioma microenvironment
Resolving pleural mesothelioma heterogeneity through spatial transcriptomics

Resolving pleural mesothelioma heterogeneity through spatial transcriptomics
Time-of-day-dependent exercise enhances tumor suppression in breast cancer

Time-of-day-dependent exercise enhances tumor suppression in breast cancer
Single cell analyses reveal functional heterogeneity within an exhausted CD8+ TIL population that is correlated with response to checkpoint therapy in melanoma

Single cell analyses reveal functional heterogeneity within an exhausted CD8+ TIL population that is correlated with response to checkpoint therapy in melanoma
Bon(e) appétit: ketone bodies fuel prostate cancer bone metastasis

Bon(e) appétit: ketone bodies fuel prostate cancer bone metastasis
Analysis of T cell receptors reveals biomarkers of response in virotherapy-treated gliomas

Analysis of T cell receptors reveals biomarkers of response in virotherapy-treated gliomas
Development of breast adipose-cancer co-culture model to decipher the impact of lipid heterogeneity on triple-negative breast cancer

Development of breast adipose-cancer co-culture model to decipher the impact of lipid heterogeneity on triple-negative breast cancer
FGFR inhibitor, erdafitinib, reshapes prostate cancer skeletal metastases via modulation of cancer-stemness and tumor-bone interface

FGFR inhibitor, erdafitinib, reshapes prostate cancer skeletal metastases via modulation of cancer-stemness and tumor-bone interface
Physics-guided deep learning for spatiotemporal prediction of melanoma evolution

Physics-guided deep learning for spatiotemporal prediction of melanoma evolution
Type 1 conventional dendritic cell therapy coordinates tumor control in murine melanoma

Type 1 conventional dendritic cell therapy coordinates tumor control in murine melanoma
Alpha particles radiotherapy combined with anti-CTLA-4 AND ATR inhibition induce durable local tumor control and abscopal responses in pancreatic cancer

Alpha particles radiotherapy combined with anti-CTLA-4 AND ATR inhibition induce durable local tumor control and abscopal responses in pancreatic cancer
P300/CBP blockade boosts therapeutic efficacy of DELTA-24-RGD against diffuse midline glioma

P300/CBP blockade boosts therapeutic efficacy of DELTA-24-RGD against diffuse midline glioma
Deep learning and retrieval-augmented generation for skin cancer diagnosis and clinical decision support

Deep learning and retrieval-augmented generation for skin cancer diagnosis and clinical decision support
Effects of KRAS mutations to tumor microenvironment of lung adenocarcinoma

Effects of KRAS mutations to tumor microenvironment of lung adenocarcinoma
STEM-T: ex vivo P4HA1 inhibition enhances therapeutic T cell persistence and function against tumor microenvironment driven exhaustion

STEM-T: ex vivo P4HA1 inhibition enhances therapeutic T cell persistence and function against tumor microenvironment driven exhaustion
Limiting metastatic breast cancer progression by targeting MK2 stromal signaling

Limiting metastatic breast cancer progression by targeting MK2 stromal signaling
SWLVRM: stochastic wavelet-based Lotka-Volterra and Rosenzweig MacArthur models of entangled multi-layer networks underpinning NSCLC multi-scale ecosystem dynamics

SWLVRM: stochastic wavelet-based Lotka-Volterra and Rosenzweig MacArthur models of entangled multi-layer networks underpinning NSCLC multi-scale ecosystem dynamics
Reprogramming translation regulation to remodel the triple-negative breast cancer ecosystem

Reprogramming translation regulation to remodel the triple-negative breast cancer ecosystem
Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche

Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche
TME and molecular characteristics of KRASQ61 mutated gastrointestinal malignancies and clinical outcomes

TME and molecular characteristics of KRASQ61 mutated gastrointestinal malignancies and clinical outcomes
Interferon lambda retards melanoma growth in mice

Interferon lambda retards melanoma growth in mice
Zoledronate inhibits anaplastic thyroid cancer bone metastases: mechanistic insight into ATC-bone interactions

Zoledronate inhibits anaplastic thyroid cancer bone metastases: mechanistic insight into ATC-bone interactions
Targeting P4HA1 to reprogramming T-cells to enable durable antitumor immunity in anti-PD1 resistant solid tumors

Targeting P4HA1 to reprogramming T-cells to enable durable antitumor immunity in anti-PD1 resistant solid tumors
Tumor-intrinsic KRAS activation and lilrbshigh macrophages contribute to recurrence in pancreatic ductal adenocarcinoma

Tumor-intrinsic KRAS activation and lilrbshigh macrophages contribute to recurrence in pancreatic ductal adenocarcinoma
In vivo profiling the activity of extracellular proteases in the tumor microenvironment

In vivo profiling the activity of extracellular proteases in the tumor microenvironment
Microbiota-dependent model of immune checkpoint inhibitor colitis characterized by inflammatory immune cells and altered hematopoiesis

Microbiota-dependent model of immune checkpoint inhibitor colitis characterized by inflammatory immune cells and altered hematopoiesis
A spatial proteomic atlas of desmoplastic small round cell tumors reveals inter- and intra-tumoral heterogeneity

A spatial proteomic atlas of desmoplastic small round cell tumors reveals inter- and intra-tumoral heterogeneity
Comprehensive atlas of leukemia and its microenvironment uncovers t cell diversity and remodeling

Comprehensive atlas of leukemia and its microenvironment uncovers t cell diversity and remodeling
Investigating the cooperation of P53 status and mutant KRAS in driving non-small cell lung cancer in vivo

Investigating the cooperation of P53 status and mutant KRAS in driving non-small cell lung cancer in vivo
Single cell and spatial transcriptomics reveals novel theraputic targets for rare liver cancer fibrolamellar carcinoma

Single cell and spatial transcriptomics reveals novel theraputic targets for rare liver cancer fibrolamellar carcinoma
Efficacy of pleural mesothelioma organoid culture in restoring tumorigenic phenotype from traditional 2D culture

Efficacy of pleural mesothelioma organoid culture in restoring tumorigenic phenotype from traditional 2D culture
From tumor allies to tertiary lymphoid structures: mertki reprogramming of monocytes and macrophages in TNBC

From tumor allies to tertiary lymphoid structures: mertki reprogramming of monocytes and macrophages in TNBC
A strategic framework for modeling abnormal quiescence that drives cancer evolution, and for preclinical development of therapies to prevent recurrence and metastasis in high-risk patients

A strategic framework for modeling abnormal quiescence that drives cancer evolution, and for preclinical development of therapies to prevent recurrence and metastasis in high-risk patients
MRTX1133 is a potent non-covalent KRAS (G12C) inhibitor with tissue-specific activity

MRTX1133 is a potent non-covalent KRAS (G12C) inhibitor with tissue-specific activity
Developing GPR56-targeted antibody-drug conjugates for triple-negative breast cancer treatment

Developing GPR56-targeted antibody-drug conjugates for triple-negative breast cancer treatment
Elucidation of mechanisms underlying proteasome addiction in ewing sarcoma

Elucidation of mechanisms underlying proteasome addiction in ewing sarcoma
BATF2 is a glutamine-responsive tumour suppressor essential for type-i interferon-dependent anti-tumour immunity

BATF2 is a glutamine-responsive tumour suppressor essential for type-i interferon-dependent anti-tumour immunity
Novel immunoregulatory roles of NONO and CGAMP in glioma viroimmunotherapy

Novel immunoregulatory roles of NONO and CGAMP in glioma viroimmunotherapy
Engineering conditionally active antibodies for selective activation in the tumor microenvironment

Engineering conditionally active antibodies for selective activation in the tumor microenvironment
Chrono-timed exercise optimizes its anti-breast cancer effects

Chrono-timed exercise optimizes its anti-breast cancer effects
Nelisa high-throughput protein profiling applied to the radiohead cohort: insights from the largest plasma proteomics study of patients receiving checkpoint inhibitor therapy

Nelisa high-throughput protein profiling applied to the radiohead cohort: insights from the largest plasma proteomics study of patients receiving checkpoint inhibitor therapy
Multiscale modeling of tumor-bone interactions reveals resistance mechanisms and therapeutic vulnerabilities

Multiscale modeling of tumor-bone interactions reveals resistance mechanisms and therapeutic vulnerabilities
Spatial transcriptomics identifies evolution of tumor microenvironmental phenotyes associated with the lung premalignancy and adenocarcinoma continuum

Spatial transcriptomics identifies evolution of tumor microenvironmental phenotyes associated with the lung premalignancy and adenocarcinoma continuum
Obese breast adipose stromal cells: characterization and crosstalk with triple-negative breast cancer

Obese breast adipose stromal cells: characterization and crosstalk with triple-negative breast cancer
Olanzapine restores appetite but fails to preserve muscle and fat mass in the c-26 model of cancer cachexia

Olanzapine restores appetite but fails to preserve muscle and fat mass in the c-26 model of cancer cachexia
Juvenile myelomonocytic leukemias and its mutational landscape by whole exome sequencing

Juvenile myelomonocytic leukemias and its mutational landscape by whole exome sequencing
Arsenic-based antineoplastic drugs kill cancer cells that thrive without oxphos

Arsenic-based antineoplastic drugs kill cancer cells that thrive without oxphos
Genetic evolution of immune escape across cancers

Genetic evolution of immune escape across cancers
Spatial coupling of morphology and transcriptomics in immunotherapy-treated glioblastoma

Spatial coupling of morphology and transcriptomics in immunotherapy-treated glioblastoma
CCR7+ dendritic cells drive t effector cell response and enhance Tumor control upon immune check blockade therapy

CCR7+ dendritic cells drive t effector cell response and enhance Tumor control upon immune check blockade therapy
A sting agonist payloaded, tumor-specific antibody sensitizes murine pancreatic cancer to immune checkpoint blockade

A sting agonist payloaded, tumor-specific antibody sensitizes murine pancreatic cancer to immune checkpoint blockade
Epiregulin and Amphiregulin as Antibody-Drug Conjugate Targets in Colorectal Cancer

Epiregulin and Amphiregulin as Antibody-Drug Conjugate Targets in Colorectal Cancer
Mitochondrial protein translation is a functional dependency in chemo-refractory triple negative breast cancer

Mitochondrial protein translation is a functional dependency in chemo-refractory triple negative breast cancer
Benchmark-informed deconvolution to resolve tumor microenvironment heterogeneity

Benchmark-informed deconvolution to resolve tumor microenvironment heterogeneity
Host–environment genomic instability in the oral tumor ecosystem: non-invasive mouth-rinse challenge-comet in vapers

Host–environment genomic instability in the oral tumor ecosystem: non-invasive mouth-rinse challenge-comet in vapers
Inference of unmeasured features in spatial proteomics data using SCRNA-SEQ references

Inference of unmeasured features in spatial proteomics data using SCRNA-SEQ references
Spatial proteomics of bone marrow uncovers spatially segregated immunosuppressive mechanisms and niche-specific structural support in TP53 mutant acute myeloid leukemia

Spatial proteomics of bone marrow uncovers spatially segregated immunosuppressive mechanisms and niche-specific structural support in TP53 mutant acute myeloid leukemia
Unveiling the distinct tumor microenvironment in early-onset pancreatic cancer

Unveiling the distinct tumor microenvironment in early-onset pancreatic cancer
MALAT1 induces resistance to icis by increasing oxidative phosphorylation (oxphos) in malignant cells and fostering immunosuppression within the TME of NSCLC

MALAT1 induces resistance to icis by increasing oxidative phosphorylation (oxphos) in malignant cells and fostering immunosuppression within the TME of NSCLC
Senescent cancer-associated fibroblasts promote collective migration in breast cancer

Senescent cancer-associated fibroblasts promote collective migration in breast cancer
Integrating SCRNA-SEQ and SCDNA-SEQ to reveal functional pathways in radiation-resistant tumor cells from patients with esophageal cancer

Integrating SCRNA-SEQ and SCDNA-SEQ to reveal functional pathways in radiation-resistant tumor cells from patients with esophageal cancer
JAK inhibition modulates polarization of macrophages to enhance viroimmunotherapy against gliomas

JAK inhibition modulates polarization of macrophages to enhance viroimmunotherapy against gliomas
Deciphering the glycorna-protein interactome in tumor

Deciphering the glycorna-protein interactome in tumor
Spatial transcriptomic landscape of colorectal cancer in the context of metastases and minimal residual disease

Spatial transcriptomic landscape of colorectal cancer in the context of metastases and minimal residual disease
When gut stem cells talk to the immune system: impacts on remote tumor

When gut stem cells talk to the immune system: impacts on remote tumor
Chromatin introversion in sickle cell disease promotes T cell ferroptosis

Chromatin introversion in sickle cell disease promotes T cell ferroptosis
Use of a novel antibody labeling method to investigate leukocyte migration into tumors following PD-1 immunotherapy

Use of a novel antibody labeling method to investigate leukocyte migration into tumors following PD-1 immunotherapy
Somatic TP53 mutations drive T and NK cell dysfunction in AML and can be rescued by reactivating wild type P53

Somatic TP53 mutations drive T and NK cell dysfunction in AML and can be rescued by reactivating wild type P53
Development of image analysis tools to study in vitro natural killer cell dynamics and cytotoxicity against renal cancer cells

Development of image analysis tools to study in vitro natural killer cell dynamics and cytotoxicity against renal cancer cells
The tumor-sentinel lymph node immunomigratome reveals ccr7⁺ dendritic cells drive response to sequenced immunoradiotherapy

The tumor-sentinel lymph node immunomigratome reveals ccr7⁺ dendritic cells drive response to sequenced immunoradiotherapy
Investigating the role of quaking-mediated lipid metabolism alterations in genomic instability and ECDNA-driven tumor evolution in glioblastoma

Investigating the role of quaking-mediated lipid metabolism alterations in genomic instability and ECDNA-driven tumor evolution in glioblastoma
Transcriptomic plasticity is a hallmark of metastatic pancreatic cancer

Transcriptomic plasticity is a hallmark of metastatic pancreatic cancer
CD83 on CCR7+DC limits intratumoral CD8 responses and promotes tumor growth

CD83 on CCR7+DC limits intratumoral CD8 responses and promotes tumor growth
Evaluation of EGFR and LGR5 dual-targeting therapeutic strategies for the improved treatment of colorectal cancer

Evaluation of EGFR and LGR5 dual-targeting therapeutic strategies for the improved treatment of colorectal cancer
Engineering red blood cells to sequester off-target cancer Immunotherapeutics

Engineering red blood cells to sequester off-target cancer Immunotherapeutics
Investigating the role of allelic imbalance in pancreatic cancer aggressiveness, survival and therapeutic resistance

Investigating the role of allelic imbalance in pancreatic cancer aggressiveness, survival and therapeutic resistance